Computing tools for analysing the pathological levels of serum transaminases

Authors

  • Maria Irina BRUMBOIU Epidemiology, Department of Community Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Victor Babes str., no. 8, Cluj-Napoca, Romania
  • Peguy Brice ASSOMO NDEMBA 2Faculty of Medicine and Biomedical Sciences, University of Yaounde I, BP 337, Yaounde, Republic of Cameroon 3Eugen Ionescu Postdoctoral scholarship recipient in Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Victor Babes str., no. 8, Cluj-Napoca, Romania
  • Irina CAZACU Pharmacology, Physiology, Pathophysiology, Department Pharmacy 2, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Victor Babes str., no. 8, Cluj-Napoca, Romania

Keywords:

Computing tools, Serum transaminases

Abstract

Aim: Serum transaminases are frequently tested for diagnostic purposes by comparing them with the considered normal values. The aim of this study was to carry out a detailed analysis on the pathological values of serum transaminases, recorded in the medical practice of the Cluj area. Material and method: A cross-sectional study was conducted with trainee doctors working in Cluj-Napoca hospitals, between 2004 and 2010. The common database, the descriptive statistic and tools for an extended analysis were conducted in Excel. Results: In the survey’s cumulative sample of 1 725 hospitalised patients, 52.6% were male, 63.1% from urban area, with a mean age of 28.5 years and hospitalized for 12.7 days on average. During a hospitalization, the serum enzymes were repeated up to 15 times. Median levels ranged from 265 to 960 IU/L for alanine transaminase (ALT) and from 117 to 685 IU/L for aspartate transaminase (AST). The main diagnoses were hepatitis A (51.2% of cases), acute or chronic hepatitis B (17.4%) and C (6%). Levels four times higher than threshold values were reached only in the first quartile for ALT, and from the second in the case of AST. Conclusion: The serum transaminases are frequently monitored during a hospitalization, mainly leading to a diagnosis of primary or secondary hepatitis. However, one in six patients remains without a complete diagnosis and for a quarter of patients the diagnosis accuracy is questionable. More evaluations are needed for selecting appropriate measures to improve the diagnostic performance.

Author Biographies

Maria Irina BRUMBOIU, Epidemiology, Department of Community Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Victor Babes str., no. 8, Cluj-Napoca, Romania

Epidemiology, Department of Community Medicine

Peguy Brice ASSOMO NDEMBA, 2Faculty of Medicine and Biomedical Sciences, University of Yaounde I, BP 337, Yaounde, Republic of Cameroon 3Eugen Ionescu Postdoctoral scholarship recipient in Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Victor Babes str., no. 8, Cluj-Napoca, Romania

Faculty of Medicine and Biomedical Sciences

Irina CAZACU, Pharmacology, Physiology, Pathophysiology, Department Pharmacy 2, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Victor Babes str., no. 8, Cluj-Napoca, Romania

Pharmacology, Physiology, Pathophysiology, Department Pharmacy 2

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Published

31.03.2019

How to Cite

1.
BRUMBOIU MI, ASSOMO NDEMBA PB, CAZACU I. Computing tools for analysing the pathological levels of serum transaminases. Appl Med Inform [Internet]. 2019 Mar. 31 [cited 2024 Apr. 22];41(1):24-32. Available from: https://ami.info.umfcluj.ro/index.php/AMI/article/view/655

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