Cervical Lesions and Cellular Atypia in a Female Population from Transylvania
Keywords:Cytological technic, Papanicolaou test, Neoplasia, Human Papillomavirus (HPV), Premalignant, Intraepithelial lesion
Introduction: The purpose of this study was to detect the types of the cervix lesions and to establish the correlations between age, environment of origin, diagnosis and gravity of the lesions. Methods: In the period 2009-2012, all cervical secretions from female subjects presented at Integrated Outpatient Unit, of the Clinical Hospital for Infectious Diseases, Cluj-Napoca, Romania were tested by Babeş-Papanicolaou examination. Babeş-Papanicolaou cytological smear was performed according to the 2001 Bethesda System criteria. Results: From 3153 cervical secretions (2736 female subjects from urban areas and 417 female subjects from rural areas) with age 10 - 87 years, 2899 (91.9%) smears (372 women from rural area and 2527 women from urban area) had normal appearance. Premalignant or malignant lesions (positive cases) were detected in 254 (8.1%) smears (45 (12.1%) cases from rural area, 209 (8.3%) cases from urban area). In the urban area, most positive cases were recorded in the age range of 45-54 years, while in the rural areas in the age range of 35-44 years. The multivariate logistic regression analysis showed that environment and age significantly influenced the occurrence of positive cases (OR=1.44 95% CI 1.02-2.02, p=0.04 for rural area, OR=0.71 95% CI 0.60-0.85, p<0.001 for age). The correlation between age and the degree of severity diagnosis (r=-0.09, p=0.14) was not significant. Conclusions: Cervical lesions detected through Babeş-Papanicolaou test in adult women are more common in the rural area.
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