Abstract

Since there are no major differences in terms of their efficiency, the choice of an NSAID regimen is naturally to be directed towards those NSAIDs that have proven a favourable safety profile (low side effects). However, it should be remembered that the risk of side effects may change depending on dose and time of administration. Considering the properties of an "ideal" NSAIDs (high efficiency, low toxicity - minimal side effects, simple regimen, reduced abandon rates, increased treatment compliance, reduced cost), we determined the hierarchy of fourteen NSAIDs through two statistical methods adjusted to the interval data, ITPOSIS1 and ITPOSIS2. The different hierarchies obtained by the two methods are justified by the difference between the two ranking methods, namely the method to calculate the distance to the ideal solution.

Keywords

NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) ranking, NSAIDs side effects (SE), Ranking methods, Interval technique for order preference by similarity to ideal Solution