Lipid Parameters in Patients with Polycystic Ovary Syndrome

Authors

  • Cristian Ioan IUHAS University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj-Napoca, Romania Second Department Of Obstetrics and Gynecology, "Dominic Stanca" Clinic Cluj-Napoca, Romania
  • Nicolae COSTIN Second Department Of Obstetrics and Gynecology "Dominic Stanca" Clinic Cluj-Napoca University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj-Napoca, Romania
  • Dan MIHU Second Department Of Obstetrics and Gynecology "Dominic Stanca" Clinic Cluj-Napoca University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj-Napoca, Romania

Keywords:

Polycystic ovary syndrome, Dyslipidemia, Cholesterol

Abstract

The purpose of our study was to investigate the lipid profile in patients with polycystic ovary syndrome (PCOS). Methods: a retrospective review of the medical records of female patients addressing for a consultation in a private healthcare network in Cluj-Napoca between 2009 and 2011 was performed.  Patients with complete lipid profile and without previous treatment were included in the PCOS group. PCOS was diagnosed using Rotterdam criteria for PCOS. Healthy female patients matched for age but without PCOS were included in the control group. Results: Compared with healthy women, women with PCOS presented higher total cholesterol levels (mean difference = 27.5 mg/dl for total cholesterol, p = 0.004) and LDL-cholesterol (mean difference = 38.1 mg/dl, p < 0.001). HDL-cholesterol displayed lower levels in PCOS patients compared with healthy women (44.4±12.2 mg/dl vs. 50.5±12.2 mg/dl, p = 0.02). No difference was observed between groups in terms of triglycerides levels. In regression analysis both total cholesterol and LDL-cholesterol were positively associated only with the presence of PCOS (β = 0.30, p = 0.01 for total cholesterol, β = 0.44, p<0.001 for LDL-cholesterol). No association was observed between HDL-cholesterol levels and the presence of PCOS. Conclusion: The results of our study show that women with PCOS have altered lipid profile, with higher cholesterol levels (both total and LDL) and lower HDL cholesterol compared with healthy women. These lipid parameters were associated with the presence of PCOS and not with parameters describing body weight.

Author Biography

Cristian Ioan IUHAS, University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj-Napoca, Romania Second Department Of Obstetrics and Gynecology, "Dominic Stanca" Clinic Cluj-Napoca, Romania

Iuhas Cristian-Ioan MD
Obstetrics and Gynecology Specialist
Assistant Professor
Second Department Of Obstetrics and Gynecology
"Dominic Stanca" Clinic Cluj-Napoca
University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj-Napoca, Romania

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Published

24.11.2012

How to Cite

1.
IUHAS CI, COSTIN N, MIHU D. Lipid Parameters in Patients with Polycystic Ovary Syndrome. Appl Med Inform [Internet]. 2012 Nov. 24 [cited 2024 Mar. 28];31(4):27-32. Available from: https://ami.info.umfcluj.ro/index.php/AMI/article/view/389

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