Accuracy of Neutrophil Gelatinase-Associated Lipocalin in Detecting Acute Kidney Injury after Urogenital Robotic Assisted Laparoscopic Surgery under General Anesthesia

Authors

  • Orsolya MIHÁLY County Urgency Clinical Hospital Cluj, ICU and Anesthesiology II Department. Cluj Napoca 1-3 Clinicilor, 400006 Cluj Napoca, Cluj, Romania.
  • Sorana D. BOLBOACA "Iuliu Hatieganu" University of Medicine and Pharmacy Cluj-Napoca
  • Rodica RĂHĂIAN County Urgency Clinical Hospital Cluj, Immunology Department. Cluj Napoca 1-3 Clinicilor, 400006 Cluj Napoca, Cluj, Romania.
  • Constantin BODOLEA City Clinical Hospital Cluj, ICU and Anesthesiology Department, 11 Tabacarilor, 400139 Cluj Napoca, Cluj, Romania.
  • Cipriana CHIRA City Clinical Hospital Cluj, ICU and Anesthesiology Department, 11 Tabacarilor, 400139 Cluj Napoca, Cluj, Romania.
  • Tudor CRISTEA City Clinical Hospital Cluj, ICU and Anesthesiology Department, 11 Tabacarilor, 400139 Cluj Napoca, Cluj, Romania.
  • Ana OBLEZNIUC City Clinical Hospital Cluj, ICU and Anesthesiology Department, 11 Tabacarilor, 400139 Cluj Napoca, Cluj, Romania.
  • Zoltán A. MIHÁLY City Clinical Hospital Cluj, Urology Department. 11 Tabacarilor, 400139 Cluj Napoca, Cluj, Romania.
  • Ioan COMAN City Clinical Hospital Cluj, Urology Department. 11 Tabacarilor, 400139 Cluj Napoca, Cluj, Romania.

Keywords:

Acute kidney injury, Biomarker, Neutrophil gelatinase associated lipocalin, General anesthesia, Robotics

Abstract

The aim of this study was to demonstrate the accuracy of NGAL in detecting Acute Kidney Injury (AKI) after urogenital robotic surgery in general anesthesia. Methods: A prospective longitudinal observational study, which included patients scheduled for elective robotic surgery under general anesthesia. The serum and urine NGAL at induction, 6 hours and 12 hours were determined. Serum creatinine was measured preoperatively and daily 4 days postoperatively. AKI was defined as the absolute growth of serum creatinine by 0.3 mg/dl over baseline within 48 hours postoperatively. Results: 24 patients were enrolled in the study. AKI occurred in 38% of patients. Serum NGAL increased significantly at 6 hours and 12h, compared to baseline, with a higher increase in the group of patents without AKI. There were no significant results for urine NGAL. A link was observed between the values of serum NGAL, with associated significance p<0.0001. The correlations between urine NGAL were not significant. The predictive value of NGAL, analyzed by cross-tabulation, OR was 3 for baseline value and 5.33 for the values measured at 6 hours and 12 hours, but with no statistical significance. Conclusions: The modifications of the NGAL levels, measured at 6 hours and 12 hours from the induction of anesthesia, were significant with more importance at 6 hours and in patients without AKI. Serum NGAL had no predictive value for AKI, but the risk to develop AKI was 3 times higher for baseline determination and 5 times at 6 and 12 hours.

Author Biography

Sorana D. BOLBOACA, "Iuliu Hatieganu" University of Medicine and Pharmacy Cluj-Napoca

Department of Medical Informatics and Biostatistics

Assist. Prof., Ph.D., M.Sc., M.D.

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Published

13.06.2012

How to Cite

1.
MIHÁLY O, BOLBOACA SD, RĂHĂIAN R, BODOLEA C, CHIRA C, CRISTEA T, OBLEZNIUC A, MIHÁLY ZA, COMAN I. Accuracy of Neutrophil Gelatinase-Associated Lipocalin in Detecting Acute Kidney Injury after Urogenital Robotic Assisted Laparoscopic Surgery under General Anesthesia. Appl Med Inform [Internet]. 2012 Jun. 13 [cited 2024 Jun. 19];30(2):47-56. Available from: https://ami.info.umfcluj.ro/index.php/AMI/article/view/380

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