Parathyroid Gland Function in Kidney Transplanted Patient: A single Center Experience

Abstract

Introduction: Information on the time course of serum parathormone levels after renal transplantation is scanty. Both the abrupt cessation of calcium-containing phosphorus binders and vitamin D (analogs) at the time of surgery and the recovery of renal function may be hypothesized to affect parathyroid gland. This study firstly examined frequency distribution of various biochemical parameters such as alkaline phosphatase (ALP), phosphorus (P), intact parathormone (iPTH) and calcium (Ca) in renal transplanted patients and secondly examined the relationship between these parameters and various demographic data of renal transplanted recipients. Material and Method: we studied 72 renal transplanted patients (47 men and 25 women with mean ages of 44 ± 12 years and mean body mass index of 24.2 ± 3.9. Serum Ca, P, ALP and serum iPTH were measured. Results: In this study, mean serum Ca and iPTH were 9.5 ± 0.7mg/dL and18.4 ± 8.2 Pg/mL (median=16.5). Mean serum ALP was 169 ± 133 IU/L (median=131). In this study, there was a negative relationship between serum iPTH and creatinine clearance (r=-0.44 P< 0.001). There was no correlation between the duration of renal transplantation and serum iPTH (P> 0.05). There were inverse correlations of serum ALP with age (r=-0.35 P= 0.02) and duration of kidney transplantation (r=-0.29 P= 0.01). Conclusions: In contrast to previous findings, in this group of patients, there was not secondary hyperparathyroism or significantly increased bone activity. The results showed suppressed parathormone secretion. The reason may be due to excessive intake of  calcium and Vitamin D  analogues, which suppress the parathyroid gland, and may prone these patients to adynamic bone disease.