Objectives: A comparative research regarding the occurrence and evolution patterns of the HIV-AIDS epidemic between Romania and the major areas (Sub-Saharan Africa (SSA) and the USA, respectively) in order to establish the current trends of the diseases and  the specific prognosis. Material and Methods: The research represents a systematic study over the entire period, of the HIV-AIDS pandemic from 1981-2008, based on specialty literature published in English or Romanian.  In addition to theses, published articles, materials presented at conferences and congresses, reports and information from the main governmental and international organizations such as WHO, CDC, UNAIDS have been consulted. Results: Romania was the first country in Central and Eastern Europe to announce the diagnosis of an AIDS case in 1985. Since then, the prevalence per 100000 population of HIV infection cases, has demonstrated an ascending trend from 0.27 in 1992 to 19.67 in 2007. HIV-AIDS infection in children from Romania is unique worldwide. Therefore, from the cumulative total of 7606 AIDS pediatric cases between 1989-2007, 4885 have had a nosocomial transmission. The mother-to-child transmission is well controlled in Romania, similar to the USA. High-risk groups (injecting drug users or men having sex with men), represent a small percentage among the Romanian HIV-AIDS and SSA cases, compared to the USA. Romania, similar to the rest of Europe and USA, has not experienced in general population.


HIV-AIDS, Sub-Saharan Africa (SSA), USA, Mother-to-child transmission (MTCT), Men having sex with men (MSM), Injecting drug users (IDU)