HDL-Cholesterol in Individuals with Type 2 Diabetes: Epidemiology and Underlying Factors
Epidemiological data showed that cardiovascular risk is 2-4 times higher in type 2 diabetic patients than in general population (after adjusting for other cardiovascular risk factors). Abnormalities of the lipid metabolism represent an important cardiovascular risk factor. The aim of this research was to study the epidemiology of low HDL cholesterol in a population-based sample of type 2 diabetes patients. The study group included 400 outpatients with type 2 diabetes, who had a mean age of 57.57± 10.40 years; diabetes duration was 9.91±7.45 years. Mean HbA1c was 8.9% and 75% of patients had a personal history of dyslipidemia. Mean HDL-cholesterol value was 38 mg/dl (40 mg/dl in women and 37 mg/dl in men). Factor analysis identified the following underlying factors that explained 68.4% of HDL-cholesterol variation: abdominal obesity, age, glycemic control and sex.