Relationship between In-Hospital Sepsis Prediction Score and Prevalence of Community-Onset Sepsis: Triage for Sepsis Risk Management

Abstract

Early diagnosis of sepsis is crucial in clinical practice. Several studies have proposed sepsis prediction models to forecast the onset of sepsis in hospitals. However, validation of prediction models for community-onset sepsis, which is sepsis developed before admission to the hospital, is insufficient. This study investigates the relationship between the in-hospital prediction model scores and community-onset sepsis. We used hierarchical logistic regression analysis to explore the relationship between sepsis prevalence and AITRICS-VC SEPS tertile categories while adjusting for potential confounders. The low-SEPS group was used as the reference group. The odds ratio (ORs) of sepsis comparing the moderate versus low SEPS group are 1.198 (95%, 1.075-3.654), and the high versus low VC-SEPS group are 8.683 (95%, 4.995-15.095). Even though the sepsis prediction model was designed to predict in-hospital sepsis, high prediction scores are related to the prevalence of community-onset sepsis. This result implies that SEPS scores can stratify sepsis risks and be considered a patient assessment tool for triage.